Conference Proceedings

Comparison of anti-HBV activity of beta-D- and beta-L-DDA-5'monophosphate prodrugs and effectiveness in combination with lamivudine.

AG Loi, A Faraj, C Pierra, G Gosselin, JL Imbach, SA Locarnini, EV Groman, RF Schinazi, JP Sommadossi

Nucleosides Nucleotides & Nucleic Acids | Published : 1999


We have investigated the effects of several beta-D-ddA 5'-monophospate (beta-D-ddAMP), and their corresponding beta-L-enantiomers prodrugs against HBV replication. All ddAMP prodrugs inhibited HBV replication in a dose-dependent manner.