Journal article

New targets and possible new therapeutic approaches in the chemotherapy of chronic hepatitis B

J Feld, J Lee, S Locarnini

Hepatology | Wiley | Published : 2003

Abstract

Chronic hepatitis B (CH-B) is characterized by in-flammatory liver disease of variable severity driven by persistent replication of the hepatitis B virus (HBV). 1 The development of a safe and effective hepatitis B surface antigen recombinant vaccine was an important milestone towards achieving control of CH-B, and its widespread implementation has dramatically reduced the incidence of infection. 2 However, for those individuals chronically infected with HBV, antiviral chemotherapy represents the best prospect of controlling active replication and thereby preventing life-threatening hepatic disease. 1 In this article, potential virus and host targets for possible future therapeutic intervent..

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