Journal article

New therapies for the treatment of chronic hepatitis B infection.

R Chin, S Locarnini

Current Opinion in Infectious Diseases | Published : 1998

Abstract

Persistent hepatitis B virus infection can lead to the development of chronic liver disease, cirrhosis and primary hepatocellular carcinoma. The only therapy of confirmed benefit in chronic hepatitis B is interferon alpha, which can lead to long-term benefit in only a third of highly selected patients. A number of new therapeutic approaches are being actively developed for treating chronic hepatitis B, including the use of nucleoside analogues, cytokines, antisense oligonucleotides, ribozymes, dominant negative mutants and DNA-based vaccines. Recent clinical trials with the nucleoside analogues have identified several important challenges for future drug development, in which the gene therap..

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