Journal article

The guanine nucleoside analog penciclovir is active against chronic duck hepatitis B virus infection in vivo.

E Lin, C Luscombe, YY Wang, T Shaw, S Locarnini

Antimicrobial Agents and Chemotherapy | Published : 1996


Ducks congenitally infected with duck hepatitis B virus (HBV) were treated with the antiviral guanine nucleoside analog penciclovir for 4 weeks at a dose of 10 mg/kg of body weight per day. The effects of treatment on viremia and intrahepatic viral genome replication, transcription, and translation were examined. In seven of eight penciclovir-treated ducks, viremia was barely detectable after a week of treatment. After 4 weeks of treatment, molecular hybridization studies showed that intrahepatic viral DNA, RNA, and protein levels were significantly reduced compared with those in placebo-treated controls. Synthesis of all viral replicative intermediates, including the normally persistent vir..

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