Journal article

Monoclonal antibodies against hepatitis A virus.

A MacGregor, M Kornitschuk, JG Hurrell, NI Lehmann, AG Coulepis, SA Locarnini, ID Gust

Journal of Clinical Microbiology | Published : 1983


Three monoclonal antibodies (K2-4F2, K3-2F2, and K3-4C8) of the immunoglobulin G2a class were raised against hepatitis A virus. The specificity of these antibodies was confirmed by immune electron microscopy, solid-phase radioimmunoassay, and in vitro neutralization in cell culture. Binding studies suggested that they all recognize closely related antigenic determinants. These monoclonal antibodies should prove to be of great value as diagnostic and research reagents.