Journal article

Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy.

Joseph JY Sung, May-Ling Wong, Scott Bowden, Choong-Tsek Liew, Alex Y Hui, Vincent WS Wong, Nancy WY Leung, Stephen Locarnini, Henry LY Chan

Gastroenterology | Published : 2005

Abstract

BACKGROUND & AIMS: This study aimed to determine whether intrahepatic hepatitis B virus (HBV) covalently closed circular (ccc) DNA and total HBV DNA levels at the end of therapy would predict sustained response to therapy. METHODS: Hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients receiving either lamivudine monotherapy or combination of peginterferon and lamivudine had liver biopsy at the end of 1 year therapy and were followed for 52 more weeks after cessation of therapy. Serum HBV DNA, intrahepatic HBV ccc DNA, and total HBV DNA levels were determined. RESULTS: Forty-seven patients, including 34 males and 13 females, were studied. Twenty-seven patients received combinati..

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