Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway
Senthilkumar Rajagopal, Divya P Kumar, Sunila Mahavadi, Sayak Bhattacharya, Ruizhe Zhou, Carlos U Corvera, Nigel W Bunnett, John R Grider, Karnam S Murthy
American Journal of Physiology-Gastrointestinal and Liver Physiology | AMER PHYSIOLOGICAL SOC | Published : 2013
Awarded by National Institute of Diabetes and Digestive and Kidney Diseases
Awarded by National Health and Medical Research Council
This work was supported by National Institute of Diabetes and Digestive and Kidney Diseases Grants (DK-28300, K. S. Murthy; DK-39957, N. W. Bunnett), the National Health and Medical Research Council (63303, 103188, N. W. Bunnett), and the Northern California Institute for Research and Education, Veterans Health Administration (C. U. Corvera).