Journal article
Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts
SK Patel, B Wai, CC Lang, D Levin, CNA Palmer, HM Parry, E Velkoska, SB Harrap, PM Srivastava, LM Burrell
Ebiomedicine | ELSEVIER | Published : 2017
Abstract
Left ventricular (LV) hypertrophy (LVH) is a heritable trait that is common in type 2 diabetes and is associated with the development of heart failure. The transcriptional factor Kruppel like factor 15 (KLF15) is expressed in the heart and acts as a repressor of cardiac hypertrophy in experimental models. This study investigated if KLF15 gene variants were associated with LVH in type 2 diabetes. In stage 1 of a 2-stage approach, patients with type 2 diabetes and no known cardiac disease were prospectively recruited for a transthoracic echocardiographic assessment (Melbourne Diabetes Heart Cohort) (n = 318) and genotyping of two KLF15 single nucleotide polymorphisms (SNPs) (rs9838915, rs67963..
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Grants
Awarded by Wellcome Trust
Funding Acknowledgements
The work in the Melbourne Diabetes Heart Cohort was supported by a Diabetes Australia Research Program grant [grant number Y12GPATS] to [S.K.P]; a Career Development Award, University of Melbourne [S.K.P]; National Heart Foundation of Australia [grant number G12M6368] to [L.M.B]; National Health and Medical Research Council of Australia/National Heart Foundation scholarship to [B.W]. The Go-DARTS study was supported by the following: genotyping was facilitated by capital funding from the Scottish Government Chief Scientist Office Generation Scotland initiative (www.generationscotland.org); The Wellcome Trust U.K. type 2 diabetes case control collection (GoDARTS2) was funded by a Wellcome Trust [grant number GR02960] and the GWAS genotyping was performed as part of the Wellcome Trust Case Control Consortium 2 [084726/Z/08/Z, 085475/Z/08/Z, 085475/B/08/Z]. Our funders had no role in the study design, data collection, data analysis, interpretation or in writing the manuscript.