Journal article

A double-blind randomized controlled trial of ibuprofen compared to placebo for uncomplicated cellulitis of the upper or lower limb

JS Davis, C Mackrow, P Binks, W Fletcher, P Dettwiller, C Marshall, J Day, W Pratt, SYC Tong

CLINICAL MICROBIOLOGY AND INFECTION | ELSEVIER SCI LTD | Published : 2017

Abstract

OBJECTIVES: Cellulitis is a common skin infection resulting in inflammation that may take weeks to resolve despite appropriate antibiotics. It is unclear whether the adjunctive use of nonsteroidal anti-inflammatory drugs hastens the resolution of inflammation in patients with cellulitis. METHODS: We conducted a double-blind, randomized controlled trial comparing ibuprofen 400 mg three times daily for 5 days with identical placebo in adults with uncomplicated cellulitis of the upper or lower limb who were treated with intravenous cefazolin via an outpatient parenteral antibiotic treatment service at one of two Australian hospitals. Participants were assessed twice daily by a study nurse. The ..

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University of Melbourne Researchers

Grants

Awarded by Australia's National Health and Medical Research Council (Career Development fellowships)


Funding Acknowledgements

Supported in part by a grant from the Northern Territory Government Research Innovation Board. Salary support was provided by Australia's National Health and Medical Research Council (Career Development fellowships to JSD (#1083105) and SYCT (#1065736)). All authors report no conflicts of interest relevant to this article.