Journal article
Cyclic voltammetry as an indicator of antioxidant activity
A Papanikos, J Eklund, WR Jackson, VB Kenche, EM Campi, AD Robertson, B Jarrott, PM Beart, FE Munro, JK Callaway
Australian Journal of Chemistry | Published : 2002
DOI: 10.1071/CH01193_CO
Abstract
A series of compounds based around combining the neuroprotective properties of non-competitive N-methyl D-aspartic acid (NMDA) receptor antagonists with antioxidant functionalities have been prepared. The redox chemistry of these compounds has been evaluated using cyclic voltammetry, and the results have been compared with their radical-scavenging properties obtained from two standard biological assays, the inhibition of lipid peroxidation (thiobarbituric acid reacting substances assay) and the Sapphire colorimetric assay. Results from these different methods show general concordance. The most effective antioxidants were substituted phenols, e.g. Trolox�. The antioxidant activity of a series..
View full abstract