Journal article

Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation

Alberto Quaglia, Venancio A Alves, Charles Balabaud, Prithi S Bhathal, Paulette Bioulac-Sage, James M Crawford, Amar P Dhillon, Linda Ferrell, Maria Guido, Prodromos Hytiroglou, Yasuni Nakanuma, Valerie Paradis, Dale C Snover, Neil D Theise, Swan N Thung, Wilson MS Tsui, Dirk J van Leeuwen

HISTOPATHOLOGY | WILEY | Published : 2016

Abstract

Clinicopathological concepts on acute and chronic liver disease have evolved rapidly during the last few years, with advances in general and specific treatment options and improved patient outcomes. The old paradigm of 'irreversibility' of cirrhosis had been challenged in major ways, and the validity of the usage of the term 'cirrhosis' has come into question. This paper addresses aetiology-based clinicopathological concepts and features that may deserve attention because they may determine disease outcome and, specifically, patterns of regression and remodelling. A variety of therapeutic interventions may influence remaining disease features after elimination of damaging agents (virus, alco..

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University of Melbourne Researchers