Journal article

Jaundice in Multiple Myeloma: The Role of Oxymetholone

GP Young, PS Bhathal, AJ Wall, JR Sullivan, TH Hurleytt

Australian and New Zealand Journal of Medicine | Published : 1978

Abstract

Jaundice complicated the course of disease in 11 (41%) of 27 consecutive patients with multiple myeloma. In only one patient was myeloma cell infiltration of the liver the sole cause of jaundice. One patient was found to have carcinoma of the pancreas. In nine jaundice developed during therapy with the bone marrow stimulant oxymetholone. Liver histology in six of the nine showed cholestatic hepatitis or a predominantly cholestatic reaction; clinical events were consistent with oxymetholone‐induced cholestasis in the remaining three. In addition to oxymetholone all patients were receiving intermittent therapy with melphalan, prednisolone and procarbazine, but such therapy was not temporally r..

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