Journal article

A quantitative analysis of the liver following ligation of the common bile duct.

JA Gall, PS Bhathal

Liver | Published : 1990

Abstract

A quantitative analysis of the liver was performed at intervals of 24, 48, 72 and 96 h and 7, 21 and 50 days following total biliary obstruction (TBO) in the Sprague-Dawley rat. During this period, the liver weight increased from 7.72 +/- 0.51 g (mean +/- SEM) in controls to 24.57 +/- 1.66 g (p less than 0.0005) at 50 days. There was a concomitant reduction in the volume proportion of the liver occupied by liver cells, from 71.37 +/- 1.36% to 21.54 +/- 3.27% (p less than 0.0005), but there were increases in the volume proportions of biliary epithelial cells (BEC) from 0.14 +/- 0.02% to 16.39 +/- 1.12% (p less than 0.0005), of other cell and tissue types from 5.50 +/- 4.89% to 30.73 +/- 2.42%..

View full abstract

University of Melbourne Researchers