The effects of cardiopulmonary bypass on total and unbound plasma concentrations of propofol and midazolam

Abstract

Objective: To examine the effects of cardiopulmonary bypass-(CPB) on total and unbound plasma concentrations of propofol and midazolam when administered by continuous infusion during cardiac surgery. Design: Prospective clinical study. Setting: University hospital. Participants: Twenty-four adult patients undergoing cardiac surgery. Interventions: Patients received either propofol or midazolam to supplement fentanyl anesthesia. Twelve patients received a propofol bolus (1 mg/kg) followed by an infusion of 3 mg/kg/hr. A second group received midazolam, 0.2 mg/kg bolus, followed by an infusion of 0.07 mg/kg/hr. Measurements and Main Results: Blood samples were collected from the radial artery ..