Journal article

Automated responsiveness test (ART) predicts loss of consciousness and adverse physiologic responses during propofol conscious sedation.

AG Doufas, M Bakhshandeh, AR Bjorksten, R Greif, DI Sessler

Anesthesiology | Published : 2001

Abstract

BACKGROUND: The authors evaluated a device designed to provide conscious sedation with propofol (propofol-air), or propofol combined with 50% nitrous oxide (N2O; propofol-N2O). An element of this device is the automated responsiveness test (ART), a method for confirming that patients remain conscious. The authors tested the hypotheses that the ART predicts loss of consciousness and that failure to respond to the ART precedes sedation-induced respiratory or hemodynamic toxicity. METHODS: The protocol consisted of sequential 15-min cycles in 20 volunteers. After a 15-min control period, propofol was infused to an initial target effect-site concentration of 0.0 microg/ml with N2O or 1.5 microg/..

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