Journal article

Propofol linearly reduces the vasoconstriction and shivering thresholds.

T Matsukawa, A Kurz, DI Sessler, AR Bjorksten, B Merrifield, C Cheng

Anesthesiology | Published : 1995


BACKGROUND: Skin temperature is best kept constant when determining response thresholds because both skin and core temperatures contribute to thermoregulatory control. In practice, however, it is difficult to evaluate both warm and cold thresholds while maintaining constant cutaneous temperature. A recent study shows that vasoconstriction and shivering thresholds are a linear function of skin and core temperatures, with skin contributing 20 +/- 6% and 19 +/- 8%, respectively. (Skin temperature has long been known to contribute approximately 10% to the control of sweating). Using these relations, we were able to experimentally manipulate both skin and core temperatures, subsequently compensat..

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