Journal article

Myocardial stress and autophagy: mechanisms and potential therapies

Lea MD Delbridge, Kimberley M Mellor, David J Taylor, Roberta A Gottlieb

NATURE REVIEWS CARDIOLOGY | NATURE PUBLISHING GROUP | Published : 2017

Abstract

Autophagy is a ubiquitous cellular catabolic process responsive to energy stress. Research over the past decade has revealed that cardiomyocyte autophagy is a prominent homeostatic pathway, important in adaptation to altered myocardial metabolic demand. The cellular machinery of autophagy involves targeted direction of macromolecules and organelles for lysosomal degradation. Activation of autophagy has been identified as cardioprotective in some settings (that is, ischaemia and ischaemic preconditioning). In other situations, sustained autophagy has been linked with cardiopathology (for example, sustained pressure overload and heart failure). Perturbation of autophagy in diabetic cardiomyopa..

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University of Melbourne Researchers