Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene

Ed Dicks; Honglin Song; Susan J Ramus; Elke Van Oudenhove; Jonathan P Tyrer; Maria P Intermaggio; Siddhartha Kar; Patricia Harrington; David D Bowtell; Mine S Cicek; Julie M Cunningham; Brooke L Fridley; Jennifer Alsop; Mercedes Jimenez-Linan; Anna Piskorz; Teodora Goranova; Emma Kent; Nadeem Siddiqui; James Paul; Robin Crawford; Samantha Poblete; Shashi Lele; Lara Sucheston-Campbell; Kirsten B Moysich; Weiva Sieh; Valerie McGuire; Jenny Lester; Kunle Odunsi; Alice S Whittemore; Natalia Bogdanova; Matthias Duerst; Peter Hillemanns; Beth Y Karlan; Aleksandra Gentry-Maharaj; Usha Menon; Marc Tischkowitz; Douglas Levine; James D Brenton; Thilo Doerk; Ellen L Goode; Simon A Gayther; Paul DP Pharoah

Journal article

Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene

Ed Dicks, Honglin Song, Susan J Ramus, Elke Van Oudenhove, Jonathan P Tyrer, Maria P Intermaggio, Siddhartha Kar, Patricia Harrington, David D Bowtell, Mine S Cicek, Julie M Cunningham, Brooke L Fridley, Jennifer Alsop, Mercedes Jimenez-Linan, Anna Piskorz, Teodora Goranova, Emma Kent, Nadeem Siddiqui, James Paul, Robin Crawford Show all

Oncotarget | IMPACT JOURNALS LLC | Published : 2017

DOI: 10.18632/oncotarget.15871

University of Melbourne Researchers

David Bowtell Author The Sir Peter MacCallum Department of Oncology

Related Projects (2)

AUSTRALIAN OVARIAN CANCER STUDY (AOCS): A MULTIDISCIPLINARY OVARIAN CANCER RESOURCE FOR THE GENOMICS ERA

Ovarian cancer is relatively uncommon and is histologically very diverse, making it difficult to analyse ovarian cancer at a molecular level..

Molecular Epidemiology of Ovarian Cancer: The Australian Ovarian Cancer Study National Clinical Follow-Up Core

Ovarian cancer is the seventh most common cancer in Australian women and fifth most common cause of cancer death, with approximately 1200 ne..

Grants

Awarded by American Cancer Society Early Detection Professorship (BYK)

Awarded by Cancer Research UK

Awarded by National Institutes for Health

Awarded by National Center for Advancing Translational Sciences

Awarded by National Health & Medical Research Council of Australia (NHMRC)

Awarded by Cancer Australia

Awarded by U.S. Army Medical Research and Materiel Command

Awarded by The Francis Crick Institute

Awarded by NATIONAL CANCER INSTITUTE

Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

Funding Acknowledgements

This work was funded by the American Cancer Society Early Detection Professorship (BYK, SIOP-06-258-01-COUN), the Cancer Councils of New South Wales, Victoria, Queensland, South Australia and Tasmania, the Cancer Foundation of Western Australia, Cancer Research UK (C1005/A7749, C315/A2621, C490/A10119, C490/A10124, C490/A16561, C1005/A12677, C1005/A6383), the Eve Appeal (The Oak Foundation), the Fred C. and Katherine B. Andersen Foundation, the National Institutes for Health (P30 CA016056, P30CA15083, P50CA136393, P50CA159981, R01CA122443, R01CA178535, R01CA61107, R01CA152990 and R01CA086381), the National Center for Advancing Translational Sciences (UL1TR000124), the National Health & Medical Research Council of Australia (NHMRC; ID400413, ID400281), Cancer Australia (509303), the Peter MacCallum Cancer Foundation and Ovarian Cancer Australia (OCA), Roswell Park Cancer Institute Alliance Foundation, Target Ovarian Cancer, the UK Department of Health, the UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge and University College London Hospitals Biomedical Research Centre; the U.S. Army Medical Research and Materiel Command (DAMD17-01-1-0729; W81XWH-08-1-0684 and W81XWH-08-1-0685).