Journal article
Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations
Ø Midttun, D Theofylaktopoulou, A McCann, A Fanidi, DC Muller, K Meyer, A Ulvik, W Zheng, XO Shu, YB Xiang, R Prentice, CA Thomson, M Pettinger, GG Giles, A Hodge, Q Cai, WJ Blot, J Wu, M Johansson, J Hultdin Show all
American Journal of Clinical Nutrition | OXFORD UNIV PRESS | Published : 2017
Abstract
Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts re..
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Awarded by Centers for Disease Control and Prevention
Funding Acknowledgements
Supported by the NIH/National Cancer Institute (NCI) [grant 1U01CA155340-01; to the Lung Cancer Cohort Consortium (LC3)], the Australian National Health and Medical Research Committee (grant 1050198; to the LC3), the US NCI [grants R37 CA070867 and UM1 CA182910 (to the Shanghai Women's Health Study), R01 CA082729 and UM1 CA173640 (to the Shanghai Men's Health Study), and R01 CA092447 and U01 CA202979 (to the Southern Community Cohort Study). The Multiethnic Cohort Study was funded in part by grant U01 CA164973. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study is supported by the Intramural Research Program of the US NCI, NIH, and by US Public Health Service contract HHSN261201500005C from the NCI, Department of Health and Human Services (DHHS). The Campaign Against Cancer and Stroke and the Campaign Against Cancer and Heart Disease acknowledge the State of Maryland, the Maryland Cigarette Restitution Fund, and the National Program of Cancer Registries of the CDC for funds that support the collection and availability of the cancer registry data. The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial is supported by contracts from the Division of Cancer Prevention and intramural research funding from the Division of Cancer Epidemiology and Genetics, NCI, US NIH, DHHS. The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial was supported by the NIH (grants, UM1CA167552, UM1CA186107, P01CA87969, and R01CA49449). CR is supported by Cancer Research UK grant (C18281/A19169) and the Medical Research Council Integrative Epidemiology Unit at the University of Bristol with funds from the Medical Research Council (MC_UU_12013/2) and the University of Bristol. This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/)