Journal article
Changes in Markers of Mineral Metabolism after Living Kidney Donation
SJ Tan, TD Hewitson, PD Hughes, SG Holt, ND Toussaint
Transplantation Direct | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
Background. Living kidney donors (LKDs) experience reduction in kidney function, however serum phosphate (sPi) levels are lower compared to patients with chronic kidney disease matched for reduced kidney function. Mineral metabolism adaptations that occur in LKDs have not been adequately investigated. To evaluate the effect of nephrectomy on markers of mineral metabolism in LKDs compared to healthy volunteers (HV) over 12 months. Methods. Mineral parameters were evaluated in twenty-one adult LKDs and twenty HVs. Parameters included sPi, intact parathyroid hormone, fibroblast growth factor-23 (FGF23), soluble Klotho (sKl) and urinary phosphate, measured prior to donation (T0), 1 month (T1), 6..
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Funding Acknowledgements
Funding sources: S.J.T. is a current recipient of a National Health and Medical Research Council (NHMRC) Postgraduate Research Scholarship. N.D.T. is supported by a Jacquot Foundation Research Establishment Award. The contents of this article are solely the views of the individual authors and do not reflect the views of NHMRC or the Jacquot Foundation.