Hard to look on the bright side: neural correlates of impaired emotion regulation in depressed youth
Katerina Stephanou, Christopher G Davey, Rebecca Kerestes, Sarah Whittle, Ben J Harrison
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE | OXFORD UNIV PRESS | Published : 2017
The cognitive regulation of emotion is impaired in major depressive disorder and has been linked to an imbalance of pre-frontal-subcortical brain activity. Despite suggestions that this relationship represents a neurodevelopmental marker of depression, few studies have examined the neural correlates of emotion regulation in depressed youth. We combined a 'cognitive reappraisal' paradigm with functional magnetic resonance imaging to study the neural correlates of emotional regulation in a large sample of non-medicated depressed adolescents and young adults (n = 53) and healthy controls (n = 64). As compared with healthy controls, young people with depression were less able to reduce negative ..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC Clinical Career Development Award
This study was funded by National Health and Medical Research Council of Australia (NHMRC) Project Grants 1064643 (Principal Investigator BJH) and 1024570 (Principal Investigator CGD). BJH is supported by a NHMRC Clinical Career Development Award (I.D. 1124472).