Journal article
Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants
Lisa M Askie, Brian A Darlow, Peter G Davis, Neil Finer, Ben Stenson, Maximo Vento, Robin Whyte
COCHRANE DATABASE OF SYSTEMATIC REVIEWS | WILEY | Published : 2017
Abstract
Background: The use of supplemental oxygen in the care of extremely preterm infants has been common practice since the 1940s. Despite this, there is little agreement regarding which oxygen saturation (SpO2) ranges to target to maximise short- or long-term growth and development, while minimising harms. There are two opposing concerns. Lower oxygen levels (targeting SpO2 at 90% or less) may impair neurodevelopment or result in death. Higher oxygen levels (targeting SpO2 greater than 90%) may increase severe retinopathy of prematurity or chronic lung disease. The use of pulse oximetry to non-invasively assess neonatal SpO2 levels has been widespread since the 1990s. Until recently there were n..
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Awarded by National Health and Medical Research Council Program
Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USA
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
Funding Acknowledgements
Internal sources NHMRC Clinical Trials Centre, University of Sydney, Australia. A/Prof Askie's time on this Cochrane Review was partly supported by a National Health and Medical Research Council Program Grant (1037786). Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USA. A/Prof Askie's time on this Cochrane Review was partly supported by a grant (R03HD 079867) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health.External sources Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USA.Editorial support of the Cochrane Neonatal Review Group has been funded with Federal funds from the Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USA, under Contract No. HHSN275201100016C.