DR5 and caspase-8 are dispensable in ER stress-induced apoptosis
Jason A Glab, Marcel Doerflinger, Christina Nedeva, Irvin Jose, George W Mbogo, James C Paton, Adrienne W Paton, Andrew J Kueh, Marco J Herold, David CS Huang, David Segal, Gabriella Brumatti, Hamsa Puthalakath
CELL DEATH AND DIFFERENTIATION | NATURE PUBLISHING GROUP | Published : 2017
The endoplasmic reticulum (ER) stress response constitutes cellular reactions triggered by a wide variety of stimuli that disturb folding of proteins, often leading to apoptosis. ER stress-induced apoptotic cell death is thought to be an important contributor to many human pathological conditions. The molecular mechanism of this apoptosis process has been highly controversial with both the receptor and the mitochondrial pathways being implicated. Using knockout mouse models and RNAi-mediated gene silencing in cell lines, our group and others had demonstrated the importance of the mitochondrial apoptotic pathway in ER stress-induced cell death, particularly the role of the pro-apoptotic BH3-o..View full abstract
Awarded by Australian National Health and Medical Research Council
JG, CN and GM are supported by LTU PhD scholarship and this project was funded by an Australian National Health and Medical Research Council Project grant APP1085328 (to HP).