Molecular imaging in the investigation of hypoglycaemic syndromes and their management
David A Pattison, Rodney J Hicks
ENDOCRINE-RELATED CANCER | BIOSCIENTIFICA LTD | Published : 2017
There has been recent progress in molecular imaging using a variety of cellular targets for the investigation of adult non-diabetic hypoglycaemic syndromes and its integration into patient management. These targets include peptide receptors (somatostatin receptors (SSTRs) and glucagon-like peptide-1 receptor (GLP-1R)) the amine precursor uptake and decarboxylation system utilising the diphydroxyphenylaline (DOPA) analogue 6-[18F]-l-fluoro-l-3,4-dihydroxyphenylalanine (18F-FDOPA), and glycolytic metabolism with 2-[18F]fluoro-2-deoxy-d-glucose (FDG). Accurate preoperative localisation and staging is critical to enable directed surgical excision or enucleation with minimal morbidity and preserv..View full abstract
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Awarded by Australian National Health and Medical Research Foundation
Professor Hicks' research is supported by an Australian National Health and Medical Research Foundation Practitioner Fellowship (NHMRC APP1108050).