Journal article

Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial.

undefined POISE Study Group, PJ Devereaux, Homer Yang, Salim Yusuf, Gordon Guyatt, Kate Leslie, Juan Carlos Villar, Denis Xavier, Susan Chrolavicius, Launi Greenspan, Janice Pogue, Prem Pais, Lisheng Liu, Shouchun Xu, German Málaga, Alvaro Avezum, Matthew Chan, Victor M Montori, Mike Jacka, Peter Choi

The Lancet | Published : 2008


BACKGROUND: Trials of beta blockers in patients undergoing non-cardiac surgery have reported conflicting results. This randomised controlled trial, done in 190 hospitals in 23 countries, was designed to investigate the effects of perioperative beta blockers. METHODS: We randomly assigned 8351 patients with, or at risk of, atherosclerotic disease who were undergoing non-cardiac surgery to receive extended-release metoprolol succinate (n=4174) or placebo (n=4177), by a computerised randomisation phone service. Study treatment was started 2-4 h before surgery and continued for 30 days. Patients, health-care providers, data collectors, and outcome adjudicators were masked to treatment allocation..

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University of Melbourne Researchers