Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): A randomised controlled trial

PJ Devereaux; H Yang; S Yusuf; G Guyatt; K Leslie; B Warriner; D Xavier; S Chrolavicius; L Greenspan; J Pogue; P Pais; L Liu; S Xu; G Málaga; A Avezum; MTV Chan; VM Montori; M Jacka; P Choi; A Ciapponi; M Garcia Dieguez; O Berwanger; RJ Hudson; T Schricker; M Tristan; Y Baidel; A Salazar; M Espinel; J Carlos Zevallos; K Leino; M Keltai; J Faller; S Islas Andrade; J Raeder; P Alonso-Coello; G Urrutia; P Gannedahl; A Phrommintikul; P Foëx; J Giles; J Sear; L Goldman; RA Caccavo; A Ferrari; LN Nicolosi; F Sierra; P Tesolin; S Barratt; D Beilby; S Bolsin; D Boyd; S Bugler; L Cope; J Douglas; S Fatovich; J Grant; R Halliwell; RK Kerridge; J Love; S March; TJ McCulloch; PS Myles; M Paech; P Peyton; C Poole; S Poustie; M Priestly; M Reeves; S Wallace; B Weitkamp; D Wolfers; M Baptista; AC Do Amara Baruzzi; C Blacher; LC Bodanese; D Campos De Albuquerque; JP Esteves; OR França Neto; LE Guiselli Gallina; NM Izukawa; FC Kallas; JF Kerr Saraiva; JA Marin-Neto; L Nigro Maia; PH Penha Rosateli; R Rabello; T Schammass Ducatti; R Aggarwala; E Argibay-Poliquin; N Badner; C Baer; WS Beattie; M Bednarowski; HA Bertozzi; G Boisvenu; A Boulton; D Brunet; GL Bryson; J Burlingham; J Campeau

Journal article

Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): A randomised controlled trial

PJ Devereaux, H Yang, S Yusuf, G Guyatt, K Leslie, B Warriner, D Xavier, S Chrolavicius, L Greenspan, J Pogue, P Pais, L Liu, S Xu, G Málaga, A Avezum, MTV Chan, VM Montori, M Jacka, P Choi, A Ciapponi Show all

Lancet | ELSEVIER SCIENCE INC | Published : 2008

DOI: 10.1016/S0140-6736(08)60601-7

Abstract

Background: Trials of β blockers in patients undergoing non-cardiac surgery have reported conflicting results. This randomised controlled trial, done in 190 hospitals in 23 countries, was designed to investigate the effects of perioperative β blockers. Methods: We randomly assigned 8351 patients with, or at risk of, atherosclerotic disease who were undergoing non-cardiac surgery to receive extended-release metoprolol succinate (n=4174) or placebo (n=4177), by a computerised randomisation phone service. Study treatment was started 2-4 h before surgery and continued for 30 days. Patients, health-care providers, data collectors, and outcome adjudicators were masked to treatment allocation. The ..

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