Journal article
Early menarche, nulliparity and the risk for premature and early natural menopause
GD Mishra, N Pandeya, AJ Dobson, HF Chung, D Anderson, D Kuh, S Sandin, GG Giles, F Bruinsma, K Hayashi, JS Lee, H Mizunuma, JE Cade, V Burley, DC Greenwood, A Goodman, MK Simonsen, HO Adami, P Demakakos, E Weiderpass
Human Reproduction | OXFORD UNIV PRESS | Published : 2017
Abstract
STUDY QUESTION: Are parity and the timing of menarche associated with premature and early natural menopause? SUMMARY ANSWER: Early menarche (≤11 years) is a risk factor for both premature menopause (final menstrual period, FMP <40 years) and early menopause (FMP 40-44 years), a risk that is amplified for nulliparous women. WHAT IS KNOWN ALREADY: Women with either premature or early menopause face an increased risk of chronic conditions in later life and of early death. Findings from some studies suggest that early menarche and nulliparity are associated with early menopause, however overall the evidence is mixed. Much of the evidence for a direct relationship is hampered by a lack of compara..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
InterLACE project is funded by the Australian National Health and Medical Research Council project grant (APP1027196). G.D.M. is supported by Australian Research Council Future Fellowship (FT120100812). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.