Journal article

The functional epistasis of 5-HTTLPR and BDNF Val66Met on emotion processing: a preliminary study

Tim Outhred, Pritha Das, Carol Dobson-Stone, Kristi Griffiths, Kim L Felmingham, Richard A Bryant, Gin Malhi, Andrew H Kemp

BRAIN AND BEHAVIOR | JOHN WILEY & SONS INC | Published : 2012

Abstract

An epistatic interaction of 5-HTTLPR and BDNF Val66Met polymorphisms has been implicated in the structure of rostral anterior cingulate cortex (rACC) and amygdala (AMY): key regions associated with emotion processing. However, a functional epistasis of 5-HTTLPR and BDNF Val66Met on overt emotion processing has yet to be determined. Twenty-eight healthy, Caucasian female participants provided saliva samples for genotyping and underwent functional magnetic resonance imaging (fMRI) during which an emotion processing protocol were presented. Confirming the validity of this protocol, we observed blood oxygen level-dependent (BOLD) activity consistent with fMRI meta-analyses on emotion processing...

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Career Development Award Fellowship


Awarded by Australian Research Council (ARC) Discovery Project


Awarded by NHMRC Project


Awarded by NHMRC Grant


Funding Acknowledgements

The authors T. O. and A. H. K. are supported by an Australian Postgraduate Award (APA) and a National Health and Medical Research Council (NHMRC) Career Development Award Fellowship (571101), respectively. This research was further supported by an Australian Research Council (ARC) Discovery Project (DP0987332) and an NHMRC Project Grant (464863) awarded to A. H. K. DNA was extracted by Genetic Repositories Australia, which is supported by an NHMRC Grant (401184). K. G. is supported by a scholarship from an ARC laureate. G. M. has received research support from AstraZeneca, Eli Lilly, Organon, Pfizer, Servier, and Wyeth.