Journal article
The impact of 5-HTTLPR on acute serotonin transporter blockade by escitalopram on emotion processing: Preliminary findings from a randomised, crossover fMRI study
T Outhred, P Das, C Dobson-Stone, KL Felmingham, RA Bryant, PJ Nathan, GS Malhi, AH Kemp
Australian and New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2014
Abstract
Objective: Benefit from antidepressant treatment such as selective serotonin reuptake inhibitors (SSRIs) may depend on individual differences in acute effects on neural emotion processing. The short (S) allele of the serotonin transporter (5-HTT)-linked polymorphic region (5-HTTLPR) is associated with both negative emotion processing biases and poorer treatment outcomes. Therefore, the aim of the present study was to explore the effects of 5-HTTLPR on the impact of the SSRI escitalopram during processing of positive and negative emotional images, as well as neutral stimuli.Methods: The study employed a double-blind, randomised, placebo-controlled crossover design on 36 healthy Caucasian fema..
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Awarded by Eli Lilly and Company
Funding Acknowledgements
This research was supported by an Australian Research Council Discovery Project Grant (DP0987332), a National Health and Medical Research Council (NHMRC) Project Grant (464863), and a NHMRC Career Development Award (571101) awarded to AHK. PD is supported through other NHMRC funding awarded to GSM. No other funding was obtained for this research.