Influence of comorbid depression on fear in posttraumatic stress disorder: An fMRI study

AH Kemp; K Felmingham; P Das; G Hughes; AS Peduto; RA Bryant; LM Williams

Journal article

Influence of comorbid depression on fear in posttraumatic stress disorder: An fMRI study

AH Kemp, K Felmingham, P Das, G Hughes, AS Peduto, RA Bryant, LM Williams

Psychiatry Research Neuroimaging | ELSEVIER IRELAND LTD | Published : 2007

DOI: 10.1016/j.pscychresns.2007.01.010

Abstract

Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal-amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity. © 2007 Elsevier Ireland Ltd. All rights reserved.