Journal article
Duration of posttraumatic stress disorder predicts hippocampal grey matter loss
K Felmingham, LM Williams, TJ Whitford, E Falconer, AH Kemp, A Peduto, RA Bryant
Neuroreport | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009
Abstract
To examine the impact of environmental stress on grey matter volume in posttraumatic stress disorder (PTSD), we investigated the relationship between duration of PTSD and grey matter volume of hippocampus and anterior cingulate cortex. Twenty-one participants with PTSD and 17 trauma-exposed controls, matched for age and sex and with no history of substance dependence, underwent a T1-weighted structural MRI scan and voxel-based morphometry was employed. After controlling for age, depression and whole-brain volume, analysis of covariance revealed significant reductions in hippocampus and rostral anterior cingulate cortex in PTSD, and there was a significant negative correlation between right h..
View full abstractGrants
Awarded by NHMRC Program
Awarded by Australian Research Council Linkage
Awarded by NHMRC Project
Awarded by NHMRC Australian Clinical Research Fellowship
Awarded by NHMRC Biomedical Research Fellowship
Awarded by Australian Research Council
Funding Acknowledgements
The authors thank the Brain Resource International Database (under the auspices of the Brain Resource Company) for support in data acquisition and methodology. This research was supported by an NHMRC Program Grant (300304) and an Australian Research Council Linkage Grant (LP0212048) and an NHMRC Project Grant (464820). KY is supported by an NHMRC Australian Clinical Research Fellowship (358676), A.H.K. by an NHMRC Biomedical Research Fellowship (358770) and L.M.W by a Pfizer senior research fellowship. The corresponding author had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.