A methodological appraisal of the impact of different classification procedures used in three different phases of the australian rheumatoid arthritis twin survey.
N Bellamy, DL Duffy, P Sambrook, RR Buchanan, PM Brooks, H Dunckley, SC Healey, S Mason, NG Martin
Inflammopharmacology | Published : 1998
AIMS: To compare methodological aspects of the impact of different classification procedures used in three phases of a twin study examining genetic factors in the aetiopathogenesis of rheumatoid arthritis (RA). METHODS: We have previously reported the results of a study of the aetiopathogenesis of RA based on the Australian Twin Registry (ATR). In the original 258 pairs self-reporting a diagnosis of RA in twin, co-twin or both, a very high false positive self-reporting rate for RA was noted (Phase 1). Subsequent diagnostic information obtained by a disease-specific questionnaire, followed by telephone interviews with subjects and review of information obtained by mail and telephone interview..View full abstract