Journal article

Preoperative and perioperative chemotherapy with 5-fluorouracil as continuous infusion in operable breast cancer expressing a high proliferation fraction: cytotoxic treatment during the surgical phase.

M Colleoni, G Curigliano, I Minchella, G Peruzzotti, F Nolè, G Mazzarol, G Renne, L Orlando, A Rocca, P Veronesi, M Intra, G Viale, MT Sandri, G Severi, A Goldhirsch

Ann Oncol | Published : 2003


BACKGROUND: Experimental data on perioperative chemotherapy (PeCT) indicate that its initiation might be most useful if administered as close as possible to the time of first 'disturbance of the tumour'. Regimens including 5-fluorouracil (5-FU) as continuous infusion are commonly used in the preoperative setting, especially for large tumours and locally advanced disease. We therefore evaluated the role of PeCT with 5-FU as continuous infusion after preoperative chemotherapy (PreCT), covering the surgical phase and acute wound healing period, in patients with breast cancer too large to attempt breast-conserving surgery upon diagnosis. PATIENTS AND METHODS: Breast cancer patients, clinical sta..

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