Hyaluronic Acid Nanoporous Microparticles with Long In Vivo Joint Residence Time and Sustained Release
Graziana Palmieri, Antonio Rinaldi, Luisa Campagnolo, Mariarosaria Tortora, Maria Federica Caso, Maurizio Mattei, Andrea Notargiacomo, Nicola Rosato, Massimo Bottini, Francesca Cavalieri
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION | WILEY-V C H VERLAG GMBH | Published : 2017
A simple approach is reported to engineer biodegradable and biocompatible nanoporous hyaluronic acid particles (NPHAs) with a characteristic sponge-like morphology and uniform size. These NPHAs can be synthesized using the concomitant cross-linking of hyaluronic acid and the cross-linking agent precipitation. The nanoporous architecture of NPHAs prevents the rapid enzymatic degradation of hyaluronic acid and controls the erosion of microparticles in physiological conditions. Once injected into an intra-articular body cavity of healthy mice, these NPHAs reside at the point-of-delivery for an extended time period, exhibiting a sustained release of hyaluronic acid. In addition, in vivo studies ..View full abstract
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Awarded by ARC Future Fellowship
G.P. and A.R. contributed equally to this work. This work was supported by the ARC Future Fellowship (to F.C., Project No. FT140100873) and the John Vaughan Scholarship from the Arthritis National Research Foundation (M.B.). The authors thank I. Mella, G. Menna, A. Mirardi, and L. Quadrini (University of Rome Tor Vergata) for experimental support.