Journal article

Hyaluronic Acid Nanoporous Microparticles with Long In Vivo Joint Residence Time and Sustained Release

Graziana Palmieri, Antonio Rinaldi, Luisa Campagnolo, Mariarosaria Tortora, Maria Federica Caso, Maurizio Mattei, Andrea Notargiacomo, Nicola Rosato, Massimo Bottini, Francesca Cavalieri

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION | WILEY-V C H VERLAG GMBH | Published : 2017

Abstract

A simple approach is reported to engineer biodegradable and biocompatible nanoporous hyaluronic acid particles (NPHAs) with a characteristic sponge-like morphology and uniform size. These NPHAs can be synthesized using the concomitant cross-linking of hyaluronic acid and the cross-linking agent precipitation. The nanoporous architecture of NPHAs prevents the rapid enzymatic degradation of hyaluronic acid and controls the erosion of microparticles in physiological conditions. Once injected into an intra-articular body cavity of healthy mice, these NPHAs reside at the point-of-delivery for an extended time period, exhibiting a sustained release of hyaluronic acid. In addition, in vivo studies ..

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University of Melbourne Researchers