Journal article
The oncoarray consortium: A network for understanding the genetic architecture of common cancers
CI Amos, J Dennis, Z Wang, J Byun, FR Schumacher, SA Gayther, G Casey, DJ Hunter, TA Sellers, SB Gruber, AM Dunning, K Michailidou, L Fachal, K Doheny, AB Spurdle, Y Li, X Xiao, J Romm, E Pugh, GA Coetzee Show all
Cancer Epidemiology Biomarkers and Prevention | AMER ASSOC CANCER RESEARCH | Published : 2017
Abstract
Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-related traits. Methods: The OncoArray can be genotyped using a novel technology developed by Illumina to facilitate efficient genotyping. The consortium developed standard approaches for ..
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Funding Acknowledgements
This work was supported by TRICL (Transdisciplinary Research for Cancer of Lung) and International Lung Cancer Consortium (ILCCO) by NIH grant U19 CA148127-01 (to C.I. Amos, J. Byun, Y. Li, X. Xiao, J. L. Forman, A. Risch, H. Bickeboller, M. Waldenberger, I. Bruske, J. Manz, P. Brennan, R. Hung, H. Shen, Y. Shi, A. Kamal, J. K. Field), DRIVE (Discovery, Biology, and Risk of Inherited Variants in Breast Cancer) by NIH grant U19 CA148065 (to D.J. Hazelett, D.F. Easton, S. Lindstrom, P. Kraft, J. Dennis, A. Dunning, K. Michailidou, L. Fachal, S. Benlloch, J. Cunningham, K. Butterbach, K. Offit, R. Schmutzler, L. Ottini, D. Vincent), CORECT (ColoRectal Transdisciplinary Study) by NIH grants U19 CA148107, R01 CA81488, P30 CA014089 (to S. Gruber, U. Peters, G. Casey), ELLIPSE (ELLIPSE, Elucidating Loci in Prostate Cancer Susceptibility) supported by U19 CA148537 (to F. Schumacher, S.A. Gayther, S.L. Schmit, C.K. Edlund, D.J. Hazelett, G.A. Coetzee, C. Haiman, S. Demetriades, D. Van Den Berg); FOCI (Follow-up of Ovarian Cancer Genetic Association & Interaction Studies) by NIH grant U19-CA148112 (to T.A. Sellers, P. Pharoah, S. Gayther, A. Monteiro, J. Schildkraut, E. Iversen) Canadian Cancer Society Research Institute (grant no. 020214; to R. Hung), R01-CA122443 (to B. Hicks) P50-CA116201, CA192393 (to F. Couch), P50-CA136393 (to J. Cunningham, F. Couch), OCAC-CA- 149429 (to C. Phelan), P30-CA15083 (to B. Hicks), R01 CA 136924 and R01 CA 190182 (to G.A. Coetzee); Cancer Research UK (C490/A8339; to A. Antoniou, P. Pharoah, A. Dunning), (C1287/A16563 and C1287/A10118) to D.F. Easton, C490/A16561 (to P. Pharoah, A. Dunning), C490/A10119 (to A. Dunning, P. Pharoah), C490/A10124 (to A. Dunning, P. Pharoah); ASTERISK: a Hospital Clinical Research Program (PHRC) and supported by the Regional Council of Pays de la Loire, the Groupement des Entreprises Francaises dans la Lutte contre le Cancer (GEFLUC), the Association Anne de Bretagne Genetique, and the Ligue Regionale Contre le Cancer (LRCC; to F. Bacot); DACHS: German Research Council (Deutsche Forschungsgemeinschaft, BR 1704/6-1, BR 1704/6-3, BR 1704/6-4, and CH 117/1-1; to C.K. Edlund), and the German Federal Ministry of Education and Research (01KH0404 and 01ER0814). Prostate Lung Colon Ovarian Screening trial: Intramural Research Program of the Division of Cancer Epidemiology and Genetics and supported by contracts from the Division of Cancer Prevention, National Cancer Institute, NIH, DHHS. The GC-HBOC (German Consortium of Hereditary Breast and Ovarian Cancer) is supported by the German Cancer Aid (grant no 110837, coordinator: to R. Schmutzler, Cologne). The PERSPECTIVE (J. Simard) project was supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research (MOP-86727, to L.E. Kelemen), the Ministere de l'Economie, Innovation et Exportation du Quebec through Genome Quebec, and the Quebec Breast Cancer Foundation, including additional funding from the Canadian Breast Cancer Foundation and the National Cancer Institute through Breast Cancer Family Registry Cohort (#1UM1CA164920-01A1); European Union Framework Programme for Research and Innovation (MSCA-IF-2014-EF-656144; to L. Fachal); The Breast Cancer Research Foundation, P30 CA08748, Andrew Sabin Foundation (to K. Offit). CIDR genotyping for the Oncoarray was conducted under contract 268201200008I (to K. Doheny) and through grant 1X01HG007491-01 (to C.I. Amos). The Norris Cotton Cancer Center (P30CA023108), The Quantitative Biology Research Institute (P20GM103534), and the Coordinating Center for Screen Detected Lesions (U01CA196386) also supported efforts of C.I. Amos.