TGF beta and BMP signaling in skeletal muscle: potential significance for muscle-related disease
Roberta Sartori, Paul Gregorevic, Marco Sandri
TRENDS IN ENDOCRINOLOGY AND METABOLISM | ELSEVIER SCIENCE LONDON | Published : 2014
The transforming growth factor beta (TGFβ) superfamily comprises a large number of secreted proteins that regulate various fundamental biological processes underlying embryonic development and the postnatal regulation of many cell types and organs. Sequence similarities define two ligand subfamilies: the TGFβ/activin subfamily and the bone morphogenetic protein (BMP) subfamily. The discovery that myostatin, a member of the TGFβ/activin subfamily, negatively controls muscle mass attracted attention to this pathway. However, recent findings of a positive role for BMP-mediated signaling in muscle have challenged the model of how the TGFβ network regulates skeletal muscle phenotype. This review ..View full abstract
Awarded by European Research Council (ERC)
Awarded by National Health and Medical Research Council, Australia (NHMRC)
This work was supported by the European Research Council (ERC) (282310-MyoPHAGY), the Italian Ministry of Education (MiUR) (PRIN 2010/2011), and the Foundation Leducq to M.S. P.G. is supported by an R.D. Wright Biomedical Research Fellowship (1046782) from the National Health and Medical Research Council, Australia (NHMRC).