Journal article

miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7

Aaron D McClelland, Michal Herman-Edelstein, Radko Komers, Jay C Jha, Catherine E Winbanks, Shinji Hagiwara, Paul Gregorevic, Phillip Kantharidis, Mark E Cooper

CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 2015

Abstract

The cytokine transforming growth factor (TGF)-β1 plays a central role in diabetic nephropathy (DN) with data implicating the miRNA (miR) miR-21 as a key modulator of its prosclerotic actions. In the present study, we demonstrate data indicating that miR-21 up-regulation positively correlates with the severity of fibrosis and rate of decline in renal function in human DN. Furthermore, concomitant analyses of various models of fibrotic renal disease and experimental DN, confirm tubular miR-21 up-regulation. The fibrotic changes associated with increased miR-21 levels are proposed to include the regulation of TGF-β1-mediated mothers against decapentaplegic homolog 3 (SMAD3)- and phosphoinositid..

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University of Melbourne Researchers