Journal article

Phenotypic characterisation of breast cancer: the role of CDC42

Eleni Chrysanthou, Kylie L Gorringe, Chitra Joseph, Madeleine Craze, Christopher C Nolan, Maria Diez-Rodriguez, Andrew R Green, Emad A Rakha, Ian O Ellis, Abhik Mukherjee



PURPOSE: The molecular landscape of breast cancer (BC), especially of the Luminal A subtype, remains to be fully delineated. Transcriptomic data show that Luminal A tumours are enriched for aberrant expression of genes in the cell division control 42 homolog (CDC42) pathway. This study aims to investigate the protein expression of CDC42 in BC and assess its clinicopathological significance. METHODS: Expression of CDC42 protein was examined by immunohistochemistry on tissue microarrays in a well-characterised cohort of 895 early-stage (I-IIIa) primary invasive BCs. RESULTS: CDC42 expression was observed in both the cytoplasm and the nucleus of BC cells. High nuclear CDC42 expression demonstra..

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Awarded by National Institute for Health Research

Funding Acknowledgements

We thank Nottingham Health Science Biobank and Breast Cancer Now for their support with tissue TMA construction. AM was supported by a lectureship from the NIHR and a Career Development Fellowship from the Pathological Society of Great Britain and Ireland for the project. KLG was supported by the Victorian Cancer Agency and a UICC Yamagiwa-Yoshida Memorial International Cancer Study Grant.