Journal article

Chemokine (C-C motif) receptor 7 (CCR7) associates with the tumour immune microenvironment but not progression in invasive breast carcinoma

Sultan N Sonbul, Kylie L Gorringe, Mohammed A Aleskandarany, Abhik Mukherjee, Andrew R Green, Ian O Ellis, Emad A Rakha

JOURNAL OF PATHOLOGY CLINICAL RESEARCH | WILEY | Published : 2017

Abstract

Some previous studies have reported that the chemokine (C-C motif) receptor 7 (CCR7) plays a role in breast cancer, is associated with lymph node metastasis and drives the site of distant metastasis. However, the impact of its expression on patient outcome and its association with tumour infiltrating inflammatory cells remain to be validated. We evaluated CCR7 protein expression by immunohistochemistry in a large well characterized cohort (n = 866) of early invasive primary breast cancers. CCR7 was expressed in the cytoplasm and membrane of tumour cells. We observed a weak positive association of high CCR7 expression when in either cellular component, but not both together, with axillary lym..

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Grants

Awarded by Academy of Medical Sciences (AMS)


Awarded by National Institute for Health Research


Funding Acknowledgements

Cell lysates were obtained from Prof. Stewart Martin (Faculty of Medicine & Health Sciences, The University of Nottingham). We thank Nottingham Health Science Biobank and Breast Cancer Now for their support with tissue TMA construction. KLG was supported by a UICC Yamagiwa-Yoshida Memorial International Cancer Study Grant.