A pilot study of the effect of (E, E)-2, 4-undecadienal on the offensive odour of trimethylamine

Abstract

Introduction: Trimethylaminuria is a malodour syndrome caused by a functional defect of flavin-containing monoxygenase 3 (FMO3), resulting in accumulation of trimethylamine in body secretions. Recently, (E, E)-2, 4-undecadienal has been shown to deodorize the offensive odour of cooked porcine intestines (chitlins). We tested the deodorizing effect of commercially available (E, E)-2, 4-undecadienal on the odour of trimethylamine (TMA) in solution. Study Participants: Eleven volunteers among staff of the Children’s Hospital at Westmead, Sydney, Australia. Methods: This was a study in three stages. In the first stage,12 volunteers sniffed and graded a commercially available trimethylamine at va..