A branching non-linear autoregressive model for the transmission of the fragile X dynamic repeat mutation.
RM Huggins, DZ Loesch, SL Sherman
Annals of Human Genetics | Published : 1998
A non-linear time series version of a model for the transmission of fragile X previously described in Ashley & Sherman (1995) is developed. The model retains the biological features of the Ashley/Sherman model but is easier to generalize and in particular allows the inclusion of covariates such as haplotype to model different paths and random effects to model family effects. The model is fitted to data from Murray et al. (1997) and its properties are illustrated in a simulation study.