Journal article

The role of angiotensin II in the central regulation of feed intake in sheep

K Sunagawa, RS Weisinger, MJ McKinley, BS Purcell, C Thomson, PL Burns

Canadian Veterinary Journal | Published : 2001


The objective was to determine the role of Angiotensin II (ANG) in the central regulation of feed intake by ruminants. As a control treatment, artificial cerebrospinal fluid (CSF) was given (over a period of 98.5 h) as a continuous intracerebroventricular (ICV) infusion (0.2 mL h–1) into the lateral ventricle of ewes (n = 5). Approximately 9 d later, the infusion was repeated with the same ewes, but the CSF contained ANG (25 g μL–1). The ewes were fed dried alfalfa chaff for 2 h once daily and both water and a 0.5 M NaCl solution were available ad libitum (except that water intake was restricted on the first day of ANG infusion). Infusion of ANG resulted in severe thirst that persisted when ..

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