Journal article

Altered responses of MeCP2-deficient mouse brain stem to severe hypoxia

Miriam Kron, Jasper L Zimmermann, Mathias Dutschmann, Frank Funke, Michael Mueller

JOURNAL OF NEUROPHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2011

Abstract

Rett syndrome (RTT) patients suffer from respiratory arrhythmias with frequent apneas causing intermittent hypoxia. In a RTT mouse model (methyl-CpG-binding protein 2-deficient mice; Mecp2(-/y)) we recently discovered an enhanced hippocampal susceptibility to hypoxia and hypoxia-induced spreading depression (HSD). In the present study we investigated whether this also applies to infant Mecp2(-/y) brain stem, which could become life-threatening due to failure of cardiorespiratory control. HSD most reliably occurred in the nucleus of the solitary tract (NTS) and the spinal trigeminal nucleus (Sp5). HSD susceptibility of the Mecp2(-/y) NTS and Sp5 was increased on 8 mM K(+)-mediated conditionin..

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Grants

Awarded by German Ministry for Education and Research via the Bernstein Center for Computational Neuroscience Gottingen


Funding Acknowledgements

This study was supported by the Deutsche Forschungsgemeinschaft Research Center for Molecular Physiology of the Brain, the German Ministry for Education and Research via the Bernstein Center for Computational Neuroscience Gottingen under Grant 01GQ0432, and the University Medical Center Gottingen (Ausstattungsmittel Juniorprofessur). Furthermore, Go4med dissertation Stipend of the University Medical Center Gottingen was awarded to J. L. Zimmermann.