Journal article

Modeling the ponto-medullary respiratory network

IA Rybak, NA Shevtsova, JFR Paton, TE Dick, WM St-John, M Morschel, M Dutschmann

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | ELSEVIER | Published : 2004

Abstract

The generation and shaping of the respiratory motor pattern are performed in the lower brainstem and involve neuronal interactions within the medulla and between the medulla and pons. A computational model of the ponto-medullary respiratory network has been developed by incorporating existing experimental data on the medullary neural circuits and possible interactions between the medulla and pons. The model reproduces a number of experimental findings concerning alterations of the respiratory pattern following various perturbations/stimulations applied to the pons and pulmonary afferents. The results of modeling support the concept that eupneic respiratory rhythm generation requires contribu..

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