Detection of recombinant human erythropoietin abuse in athletes utilizing markers of altered erythropoiesis.
R Parisotto, M Wu, MJ Ashenden, KR Emslie, CJ Gore, C Howe, R Kazlauskas, K Sharpe, GJ Trout, M Xie
Haematologica | Published : 2001
BACKGROUND AND OBJECTIVES: The detection of recombinant human erythropoietin (r-HuEPO) abuse by athletes remains problematic. The main aim of this study was to demonstrate that the five indirect markers of altered erythropoiesis identified in our earlier work were reliable evidence of current or recently discontinued r-HuEPO use. A subsidiary aim was to refine weightings of the five markers in the initial model using a much larger data set than in the pilot study. A final aim was to verify that the hematologic response to r-HuEPO did not differ between Caucasian and Asiatic subjects. DESIGN AND METHODS: Recreational athletes resident in Sydney, Australia (Sydney, n = 49; 16 women, 33 men) or..View full abstract