The impact of body mass index on the associations of lipids with the risk of coronary heart disease in the Asia Pacific region.
Yoichiro Hirakawa, Tai-Hing Lam, Timothy Welborn, Hyeon Chang Kim, Suzanne Ho, Xianghua Fang, Hirotsugu Ueshima, Il Suh, Graham Giles, Mark Woodward, undefined Asia Pacific Cohort Studies Collaboration
Prev Med Rep | Published : 2016
OBJECTIVE: To assess whether body mass index (BMI) modifies the associations of lipids with coronary heart disease (CHD). METHODS: In the Asia Pacific Cohort Studies Collaboration, total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and triglycerides (TG) were measured for 333,297, 71,777 and 84,015 participants, respectively. All participants had measured BMI, categorized into underweight, normal, high-normal, overweight and obese, using standard definitions. For each BMI subgroup the effects of lipids on CHD were estimated per 1 standard deviation (SD) increase using Cox proportional hazard models, stratified by study and sex, adjusted for age and smoking. They were compare..View full abstract