Hormone replacement therapy and accuracy of mammographic screening

Abstract

BACKGROUND: Hormone replacement therapy (HRT) is commonly used and may affect the accuracy of mammographic screening. METHODS: We examined the sensitivity, specificity, and small-cancer detection rate according to HRT use in 103,770 women in Victoria, Australia, who attended first-round screening in 1994 and who did not have a personal history of breast cancer or a breast lump or a bloodstained or watery nipple discharge at the time of screening. BreastScreen Victoria provides mammography to women aged 40 years and older every 2 years. Unconditional logistic modelling was used to adjust for age, family history, and symptom status. FINDINGS: The sensitivity of screening mammography for a 2-ye..