Hormone replacement therapy and accuracy of mammographic screening

Abstract

Background. Hormone replacement therapy (HRT) is commonly used and may affect the accuracy of mammographic screening. Methods. We examined the sensitivity, specificity, and small-cancer detection rate according to HRT use in 103,770 women in Victoria, Australia, who attended first-round screening in 1994 and who did not have a personal history of breast cancer or a breast lump or a bloodstained or watery nipple discharge at the time of screening. Breast Screen Victoria provides mammography to women aged 40 years and older every 2 years. Unconditional logistic modelling was used to adjust for age, family history, and symptom status. Findings. The sensitivity of screening mammography for a 2 y..