Progressive increase in mtDNA 3243A > G heteroplasmy causes abrupt transcriptional reprogramming
Martin Picard, Jiangwen Zhang, Saege Hancock, Olga Derbeneva, Ryan Golhar, Pawel Golik, Sean O'Hearn, Shawn Levy, Prasanth Potluri, Maria Lvova, Antonio Davila, Chun Shi Lin, Juan Carlos Perin, Eric F Rappaport, Hakon Hakonarson, Ian A Trounce, Vincent Procaccio, Douglas C Wallace
Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2014
Awarded by Simon Foundation
Awarded by National Institutes of Health
The authors thank Katelyn Sweeney and the University of Pennsylvania EM Core Facilities for technical assistance on parts of this project. This work was supported by Simon Foundation Grant 205844 and by National Institutes of Health Grants NS21328, NS070298, AG24373, and DK73691 (to D. C. W.). M. P. is supported by a postdoctoral fellowship from the Canadian Institute of Health Research Institute of Neuroscience as part of the Canadian Epigenetics, Environment, and Health Research Consortium.