Journal article

Progressive increase in mtDNA 3243A > G heteroplasmy causes abrupt transcriptional reprogramming

Martin Picard, Jiangwen Zhang, Saege Hancock, Olga Derbeneva, Ryan Golhar, Pawel Golik, Sean O'Hearn, Shawn Levy, Prasanth Potluri, Maria Lvova, Antonio Davila, Chun Shi Lin, Juan Carlos Perin, Eric F Rappaport, Hakon Hakonarson, Ian A Trounce, Vincent Procaccio, Douglas C Wallace

Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2014

University of Melbourne Researchers


Awarded by Simon Foundation

Awarded by National Institutes of Health

Funding Acknowledgements

The authors thank Katelyn Sweeney and the University of Pennsylvania EM Core Facilities for technical assistance on parts of this project. This work was supported by Simon Foundation Grant 205844 and by National Institutes of Health Grants NS21328, NS070298, AG24373, and DK73691 (to D. C. W.). M. P. is supported by a postdoctoral fellowship from the Canadian Institute of Health Research Institute of Neuroscience as part of the Canadian Epigenetics, Environment, and Health Research Consortium.