Journal article

CHRONIC-ALCOHOLIC PROXIMAL WASTING - PHYSIOLOGICAL, MORPHOLOGICAL AND BIOCHEMICAL-STUDIES IN SKELETAL-MUSCLE

I TROUNCE, E BYRNE, X DENNETT, J SANTAMARIA, J DOERY, R PEPPARD

AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE | ADIS PRESS AUSTRALASIA P/L | Published : 1987

Abstract

Electromyography, muscle histochemistry and assay of all glycolytic enzymes, phosphorylase, glycogen, carnitine and several mitochondrial marker enzymes in skeletal muscle (vastus lateralis) were carried out in two groups. One group comprised chronic alcoholic patients with prominent proximal wasting, the other was an alcoholic group with normal neuromuscular examination. Biochemical results were compared with data from control groups with normal muscle histology and with non-alcohol related type 2b fibre atrophy. Either 2b atrophy factor or 2b variability coefficient were increased in all wasted alcoholic patients, with normal values in alcoholics without wasting. Electromyography studies w..

View full abstract

University of Melbourne Researchers