Journal article
Uric acid and thiocyanate as competing substrates of lactoperoxidase
A Seidel, H Parker, R Turner, N Dickerhof, IS Khalilova, SM Wilbanks, AJ Kettle, GNL Jameson
Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2014
Abstract
Background: Lactoperoxidase plays a key role in host defense by oxidizing thiocyanate to the bactericidal agent hypothiocyanite. Results: Urate is a good substrate for lactoperoxidase and competes with thiocyanate for oxidation in vitro. Conclusion: Urate is a likely physiological substrate for lactoperoxidase. Significance: Urate may influence the bactericidal activity of lactoperoxidase. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Grants
Funding Acknowledgements
[ "This work was supported by grants from the University of Otago and the Health Research Council of New Zealand.", "Funded by a University of Otago International Doctoral Scholarship." ]