Interleukin-23 drives innate and T cell-mediated intestinal inflammation.
Sophie Hue, Philip Ahern, Sofia Buonocore, Marika C Kullberg, Daniel J Cua, Brent S McKenzie, Fiona Powrie, Kevin J Maloy
Journal of Experimental Medicine | Published : 2006
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract involving aberrant activation of innate and adaptive immune responses. We have used two complementary models of IBD to examine the roles of interleukin (IL)-12 family cytokines in bacterially induced intestinal inflammation. Our results clearly show that IL-23, but not IL-12, is essential for the induction of chronic intestinal inflammation mediated by innate or adaptive immune mechanisms. Depletion of IL-23 was associated with decreased proinflammatory responses in the intestine but had little impact on systemic T cell inflammatory responses. These results newly identify IL-23 as a driver of in..View full abstract